THE SHILNIKOV LAB

aaron
Dr. Andrey Shilnikov
Lab Head
Sajiya Jaili,
PhD student
with Dr. Igor Belykh

Jeremy Wojcik
PhD student,
NSF support

Aaron Keley
PhD student
Tingli Xing,
PhD student
Victor Bailey
BS student,
Joseph Youker
BS student,
B&B Summer Fellowship
NSF REU support

Justus Schwabedal, PhD, Visiting Scholar,
University Potstam

  enis_gunay  

 

Kristie Young

Enis Gunay, PhD
Postdoc fellow

 

Alumni
     
Matt Brooks
MS student, 2009
Paul Channell Jr.
MS Student, 1976-2011
Rene Gordon
BS student, 2011
O.Burilko,
Postdoc Visiting Scholar, Plymouth UK
 
Summer Hu
PhD student,
U Maryland
Dane Allen,
BS student
NSF REU support
Emmanuel Thomas
BS student
B&B Fellowship
 


Congratulations to Sajiya and Jeremy - 2012 PhD graduates!


Dynamics of individual neurons

Deterministic description of oscillatory activities in neurons is given within the framework of theory of dynamical systems and bifurcations. Mathematically, the corresponding, conductance based model belongs to a class of dynamical systems with several distinct time scales.  Dr. Shilnikov’s research group focuses its research on the origin of complex behavioral dynamics and preceding bifurcation sequences in neuronal models. We develop the geometric tools of slow-fast systems and the advanced, analytical and computational technique of the global bifurcation theory to model and understand in-depth the nonlinear dynamics of single neurons. 

Polyrhythms and Multistability in CPG networks

Bursting is a manifestation of the slow-fast dynamics observed in neuroscience including central pattern generators controlling animal locomotion.  The emergence of synchronous rhythms in neural networks is closely related to temporal characteristics of the coupled neurons due to both their intrinsic properties and types of synaptic coupling, inhibitory and excitatory. When cells are near the transition edge between bursting and tonic spiking, the dynamics of the network become highly sensitive to small perturbations due to changes in the architecture of the network and of strength of synaptic coupling. Research of Dr. Shilnikov’s group focuses on synergetic mechanisms of dynamical designation of pacemakers on a network endowing it with flexible synchronization properties leading to the multistability of coexistent bursting rhythms.

Prospective PhD candidates, MS and BS students in Mathematical and Computational Neuroscience, Dynamical Systems and Applied Math: contact Dr Shilnikov

Lab's publications

Jalil S., Belykh I and Shilnikov A. Spikes matter in phase-locking of inhibitory bursting networks. Phys Review E 85, 036214, 2012, doi:10.1103/PhysRevE.85.036214 [pdf]
Wojcik J. and Shilnikov A.L. Voltage interval mappings for an elliptic burster, in "Nonlinear Dynamics: New Directions," Springer Series "Nonlinear Physical Science," 2012[pdf]
Wojcik J., Clewley R, and Shilnikov A., Order parameter for bursting polyrhythms in multifunctional central pattern generators.  Physics Review E 83, 056209-6, 2011 [pdf] DOI: 10.1103/PhysRevE.83.056209
Wojcik J. and Shilnikov A.L. Voltage interval mappings for dynamics transitions in elliptic bursters, Physica D 240, 1164-1180, 2011 [pdf] http://dx.doi.org/10.1016/j.physd.2011.04.003
Hu X, Youker J, Wojcik J, Clewley R and Shilnikov A, Phase and exact models for multifunctional central pattern generators, Proc. the 4th Dynamical Systems and Control Conference, Arlington, VA, Oct 31-Nov 2, 2011 [pdf]
Jalil S., Belykh I and Shilnikov A. Spikes matter in phase-locking of inhibitory bursting networks, submitted to PRE. 2011 [pdf]
Jalil S., Belykh I., and Shilnikov A. Fast reciprocal inhibition can synchronize bursting neurons, Physics Review E 81(4), 045201-4, Rapid Communications, 2010 [pdf] Virtual Journal of Biological Physics Research: biological networks. 19(9), 2010
Belykh I., Jalil S., and Shilnikov A. Burst-duration mechanism of in-phase bursting in inhibitory networks. Regular & Chaotic Dynamics, 15(2-3), 148-160, 2010 [pdf]
Channell P., Fuwape I., Neiman A., and Shilnikov A.L., Variability of bursting patterns in a neuronal model in the presence of noise, 2009, J. Computational Neuroscience, 27(3), 527-542, [pdf] DOI 10.1007/s10827-009-0167-1
Shilnikov A.L., Gordon R. and Belykh I.V., Polyrhythmic synchronization in bursting network motifs, J. Chaos, 18, 037120, 2008, DOI: 10.1063/1.2959850 [pdf] Virtual Journal of Biological Physics Research: biological networks. 16(7), 2008.
Channell P., Cymbalyuk G. and Shilnikov A. L., Origin of bursting through homoclinic spike adding in a neuron model, Phys. Rev. Letters 98, 134101, 2007; doi: 10.1103/PhysRevLett.98.134101 [pdf] [gzip.ps].      Virtual Journal of Biological Physics, 3(7), 2007.
Channell P., Cymbalyuk, G. and Shilnikov, A. L., Applications of the Poincare mapping technique to analysis of neuronal dynamics Neurocomputing, 70 (10-12), 2007; doi:10.1016/j.neucom.2006.10.091 [pdf]