Ph.D., Emory University, 2001 Assistant Professor Member, Clinical Psychology and NBN Programs psyebm@langate.gsu.edu 404-413-6291 1172 Urban Life

Research Interests

My research focuses on social cue processing and its role in the emergence and maintenance of child and adolescent anxiety disorders. In particular, I use behavioral and neuroimaging (functional magnetic resonance imaging or fMRI) techniques to compare responses to social stimuli between youth with anxiety disorders and their psychologically healthy peers. I am especially interested in the ways in which social threat cues, such as negative emotional faces or cues of rejection or betrayal, elicit different patterns of behavior and neural activity in youth with and without anxiety disorders. Because marked gender differences exist in the incidence and prevalence of anxiety disorders at different points in development, I am also interested in how gender may moderate behavior and neural patterns of activation. I have approached these questions in two main ways. First, I have studied patterns of behavioral and neural response to static nonverbal cues of emotion such as facial expressions in patients and psychologically healthy youth. Second, I have more recently begun to examine behavioral and neural responses to dynamic, complex, ecologically valid stimuli such as simulated threatening social interactions.

Clinical Interests

Clinical practice represents a core aspect of my professional identity and one that informs both my research and my teaching. In keeping with this tight coupling of academic and clinical work, my current primary clinical interests, like my research interests, revolve around the evaluation and treatment of children and adolescents with anxiety and mood disorders. My commitment to the use of empirically supported approaches to treatment of childhood mood and anxiety is longstanding. Within this broad framework, however, I work from an eclectic, pragmatic stance that merges cognitive-behavioral, interpersonal, and family systems perspectives.

Representative Publications

Monk, C.S., Klein, R.G., Telzer, E.H., Schroth, E.A., Mannuzza, S., Moulton, J.L., Guardino, M., Masten, C.L., McClure-Tone, E.B., Fromm, S., Blair, R.J.R., Pine, D.S., Ernst, M. (in press). Amygdala and Nucleus Accumbens Activation to Emotional Facial Expressions in Adolescents at Risk for Major Depression. American Journal of Psychiatry.

Masten, C.L., Guyer, A.E., Hodgdon, H.B., McClure, E.B., Charney, D.S., Ernst, M., Kaufman, J., Pine, D.S., & Monk, C.S. (in press). Facial expression recognition among maltreated children with high rates of Post-Traumatic Stress Disorder. Child Abuse & Neglect.

McClure, E.B., Parrish, J.M., Nelson, E.E., Easter, J., Thorne, J.F., Rilling, J.K., Ernst, M. & Pine, D.S. (2007). Responses to conflict and cooperation in adolescents with anxiety and mood disorders. Journal of Abnormal Child Psychology 35, 567-577.

Guyer, A.E., McClure, E.B., Adler, A.D., Brotman, M.A., Rich, B.A., Kimes, A.S., Pine, D.S, Ernst, M., & Leibenluft, E. (2007). Specificity of facial expression labeling deficits in childhood psychopathology. Journal of Child Psychology and Psychiatry, 48, 863-871.

Pérez-Edgar, K., Roberson-Nay, R., Hardin, M.G., Poeth, K., Guyer, A., Nelson, E. E., McClure, E. B., Henderson, H., Fox, N. A., Pine, D.S., & Ernst, M. (2007). Attention Alters Neural Responses to Evocative Faces in Behaviorally Inhibited Adolescents. Neuroimage, 35, 1538-1546.

McClure, E.B., Adler, A., Monk, C.S., Cameron, J., Smith, S., Nelson, E.E., Leibenluft, E., Ernst, M., & Pine, D.S. (2007). fMRI and behavioral predictors of treatment outcome in pediatric Generalized Anxiety Disorder. Psychopharmacology, 191, 97-105.

Dickstein D. P., Nelson E. E., McClure E. B., Grimley M. E., Knopf L., Brotman M. A., Rich B. A., Pine D. S., Leibenluft E. (2007). Cognitive Flexibility in Phenotypes of Pediatric Bipolar Disorder. Manuscript accepted for publication in Journal of the American Academy of Child and Adolescent Psychiatry, 46, 341-355.

McClure, E.B., Monk, C.S., Nelson, E.E., Parrish, J.M., Adler, A., Blair, R.J.R., Fromm, S.J., Charney, D.S., Leibenluft, E., Ernst, M., & Pine, D.S. (2007). Abnormal attention modulation of fear circuit activation in pediatric Generalized Anxiety Disorder. Archives of General Psychiatry, 64, 94-106.

Leibenluft, E., Rich, B.A., Vinton, D.T., Nelson, E.E., Fromm, S.J., Berghorst, L.H., Joshi, P., Robb, A., Schachar, R.J., Dickstein, D.P., McClure, E.B., & Pine, D.S. (2007). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. American Journal of Psychiatry, 164, 52-60.

Roberson-Nay, R., McClure, E.B., Monk, C.S., Nelson, E.E., Guyer, A.E., Fromm, S.J., Charney, D.S., Leibenluft, E., Blair, J., Ernst, M., & Pine, D.S. (2006). Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An fMRI study. Biological Psychiatry, 60, 966-973.

Jazbec, S., Hardin, M.G., Schroth, E., McClure, E.B., Pine, D.S., Ernst, M. (2006). Age-related influence of contingencies on a saccade task. Experimental Brain Research, 174, 754-762.

Rich, B.A., Vinton, D.T., Roberson-Nay, R., Hommer, R.E., Berghorst, L.H., McClure, E.B., Fromm, S.J., Pine, D.S., Leibenluft, E. (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Science, 103, 8900-8905.

Monk, C.S., Nelson, E.E., McClure, E.B., Mogg, K., Bradley, B.P., Leibenluft, E., Blair, R.J.R., Chen, G., Charney, D.S., Ernst, M., Pine, D.S. (2006). Ventrolateral prefrontal cortex activation and attention bias in response to angry faces in adolescents with generalized anxiety disorder. American Journal of Psychiatry, 163, 1091-1097.

McClure, E. B., Treland, J.E., Snow, J., Dickstein, D.P., Towbin, K.E., Charney, D.S., Pine, D. S., & Leibenluft, E. (2005). Memory and learning deficits in pediatric bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 461-469.

Ernst, M., Jazbec, S., McClure, E.B., Monk, C. S., Blair, R.J.R., Leibenluft, E., & Pine, D.S. (2005). Amygdala and nucleus accumbens activation in response to receipt and omission of gains in adults and adolescents. Neuroimage, 25, 1279-1291.

Pine, D. S., Mogg, K., Bradley, B., Montgomery, L. A., Monk, C., McClure, E., Schweder, A., Ernst, M., Charney, D. S., & Kaufman, J. (2005). Attention bias to threat in maltreated children: Implications for vulnerability to stress-related psychopathology. American Journal of Psychiatry, 162, 291-296.

Nelson, E.E., Leibenluft, E., McClure, E.B., & Pine, D.S. (2005). The social reorientations of adolescence: A neuroscience perspective on the process and its relation to psychopathology. Psychological Medicine, 35, 1-12.

Monk, C.S., Nelson, E.E., Woldehawariat, G., Montgomery, L.A., Zarahn, E., McClure, E.B., Guyer, A.E., Leibenluft, E., Charney, D.S., Ernst, M., & Pine, D.S. (2004). Experience-dependent plasticity for attention to threat: Behavioral and neurophysiological evidence in humans. Biological Psychiatry, 56, 607-610.

Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., Charney, D., & Pine, D. S. (2004). Choice selection and reward anticipation: An fMRI study.  Neuropsychologia, 42, 1585-1597.

McClure, E. B., Monk, C. S., Nelson, E. E., Zarahn, E., Leibenluft, E., Bilder, R. M., Charney, D. S., Ernst, M., & Pine, D. S. (2004). A developmental examination of gender differences in brain engagement during evaluation of threat. Biological Psychiatry, 55, 1047-1055. 

Dickstein D. P., Treland J. E., Snow J, McClure E. B., Mehta M. S., Towbin K. E., Pine D. S., Leibenluft E. (2004). Neuropsychological performance in pediatric bipolar disorder.  Biological Psychiatry, 55, 32-39.

Monk, C. S., McClure, E. B., Nelson, E. E., Zarahn, E., Bilder, R. M., Leibenluft, E., Charney, D. S., Ernst, M., & Pine, D. S. (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions.  NeuroImage, 20, 420-428.

Monk, C. S., Grillon, C., Baas, J. M. P., McClure, E. B., Nelson, E. E.,  Zarahn, E., Charney, D. S., Ernst, M., & Pine, D. S. (2003).  A neuroimaging method for the study of threat in adolescents. Developmental Psychobiology, 43, 359-366.

Nelson, E. E., McClure, E. B., Monk, C. S., Zarahn, E., Leibenluft, E., Pine, D. S., & Ernst, M. (2003).  Developmental differences in neuronal engagement during implicit encoding of emotional faces: An event-related fMRI study.  Journal of Child Psychology, Psychiatry and Allied Disciplines, 44, 1015-1024.

McClure, E. B., Pope, K., Hoberman, A. J., Pine, D. S., & Leibenluft, E. (2003). Facial expression recognition in adolescents with mood and anxiety disorders. American Journal of Psychiatry, 160 , 1172-1174.

McClure, E. B., Kubiszyn, T., & Kaslow, N. J. (2002). Advances in the diagnosis and treatment of childhood mood disorders. Professional Psychology: Research and Practice, 33, 125-134.

McClure, E. B., & Nowicki, S., Jr. (2001).  Associations between social anxiety and nonverbal processing skill in preadolescent boys and girls.  Journal of Nonverbal Behavior, 25, 3-19. 

McClure, E. B., Brennan, P., Hammen, C., & LeBrocque, R. (2001).  Perceived parenting behavior as a mediator of the relationship between parent and child anxiety disorders in a high-risk sample.  Journal of Abnormal Child Psychology, 29, 1-10.

McClure, E. B. (2000). A meta-analytic review of sex differences in facial expression processing and their development in infants, children, and adolescents.  Psychological Bulletin, 126, 424-453.